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我国早在50年代中期在研制人工牛黄的同时,曾用钙盐法分离制得胆红素,该法一直延用至今。但该法工艺繁琐,溶媒耗用量大,收率低(只达0.020～0.028%)。而离子交换树脂法分离胆红素,其工艺操作并未明显简化,所用树脂须预处理和再生,收率仅达0.035%。作者采用氯仿直接提取胆红素法,大大地简化了工艺操作,节约溶媒和缩短了生产周期,其收率可达0.0469%,该法具有生产价值可用于生产。对上述三种方法考察结果如下。
In China, as early as the mid-1950s, when artificial bezoar was developed, bilirubin was separated by the calcium salt method. This method has been used until now. However, the process is cumbersome, the solvent consumption is large, and the yield is low (only 0.020-0.028%). The separation of bilirubin by ion exchange resin method, the process operation is not significantly simplified, the resin used to be pretreated and regenerated, the yield of only 0.035%. The authors used the method of direct extraction of bilirubin by chloroform, which greatly simplified the process operation, saved solvent and shortened the production cycle, and its yield was up to 0.0469%. The method has production value and can be used for production. The results of the above three methods are as follows.