很多慢性肝病中发生细胞外基质的改变.在纤维化形成过程中,基质蛋白显著增多.用过氧化酶标记的专一抗胶原抗体的方法,已在人及大鼠的肝脏证实几种主要胶原类型的超微结构,以及不同的分布状况.过去认为,胶原仅由纤维母细胞或其前体制造.近年来,体外实验研究的结果提示,包括 Extracellular matrix changes occur in many chronic liver diseases, and matrix proteins are significantly increased during the formation of fibrosis Several peroxidases-specific anti-collagen antibodies have been used to confirm several major forms of collagen in the liver of humans and rats Type of ultrastructure, and different distribution of the past that collagen is only made of fibroblasts or their precursors in recent years, the results of in vitro experimental studies suggest that including