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血管内皮细胞生长因子 (VEGF)受体信号转导途径参与细胞的迁移、增殖、生存 ,在血管新生和血管保护中具有重要的作用。VEGF受体信号转导途径可能是治疗冠状动脉粥样硬化的理想靶点。本文针对VEGF受体信号转导途径及其与冠心病治疗的研究现状予以综述。
Vascular endothelial growth factor (VEGF) receptor signal transduction pathway is involved in cell migration, proliferation and survival, and plays an important role in angiogenesis and vascular protection. VEGF receptor signal transduction pathway may be the ideal target for the treatment of coronary atherosclerosis. This review summarizes the current status of VEGF receptor signal transduction pathway and its therapeutic effect on coronary heart disease.