肝纤维化是细胞外基质在肝内过度沉积的病理改变,多数慢性肝病人都有不同程度的肝纤维化,其中25%~40%最终发展成肝硬化乃至肝癌,因此,阻断肝纤维化就成为慢性肝病治疗中的一个关键问题。为了更好地研究肝纤维化的发生机制及药物对该病的疗效和治疗途径,需要建立良好可靠的肝纤 Liver fibrosis is a pathological change in the extracellular matrix deposition in the liver, most patients with chronic liver disease have varying degrees of liver fibrosis, of which 25% to 40% eventually develop into cirrhosis and even liver cancer, thus blocking the liver fibrosis It has become a key issue in the treatment of chronic liver disease. In order to better study the mechanism of liver fibrosis and drug efficacy and treatment of the disease approach, the need to establish a good and reliable liver fiber