多重耐药 (mar)操纵子是广泛存在于肠杆菌科细菌染色体上的一个压力反应调控中心。mar位点突变或细菌暴露于诱导物时 ,其编码的转录激活蛋白MarA超表达 ,后者通过调节众多基因转录及改变细菌对药物的转运 ,使细菌对多种结构不相关的抗生素、有机溶剂及氧化作用压力的抗性增加 ,形成多重耐药 (Mar)表型。 The multi-drug resistant (mar) operon is a stress response regulator widely found on the chromosomes of Enterobacteriaceae bacteria. Mar site mutation or bacterial exposure to inducers, its encoded transcription activator MarA overexpression, the latter by regulating the transcription of many genes and alter bacterial transport of drugs, so that bacteria on a variety of structurally unrelated antibiotics, organic solvents And the resistance to oxidative stress increased, forming a multi-drug resistant (Mar) phenotype.