目的　总结胰、肾联合移植术治疗糖尿病合并尿毒症的临床体会。方法　对 3例糖尿病合并尿毒症、周围神经病变及视网膜病变患者施行不同术式的胰、肾联合移植术 ,其中 1例为胰液膀胱引流术式 ,另 2例为胰液空肠引流术式。 3例免疫抑制治疗均采用环孢素A、霉酚酸酯及泼尼松 ,其中 2例术后早期应用单克隆抗体。结果　 3例患者术后均停用胰岛素 ,血糖、C 肽以及尿素氮、肌酐均恢复正常 ;2例下肢神经传导速度及视力在术后 3个月后有不同程度的改善 ,现已存活 1 6个月、1 0个月 ,另 1例因肝功能衰竭 ,于术后 2个月死亡。结论　胰、肾联合移植术是治疗糖尿病合并尿毒症的有效手段 ,并能改善糖尿病的其它合并症 Objective To summarize the clinical experience of combined pancreas and kidney transplantation in the treatment of diabetic uremia. Methods Three cases of diabetic combined with uremia, peripheral neuropathy and retinopathy patients underwent different types of pancreas and kidney transplantation, including 1 case of drainage of pancreatic juice bladder operation, the other 2 cases of pancreatic juice jejunal drainage surgery. Three cases of immunosuppressive therapy were treated with cyclosporine A, mycophenolate mofetil and prednisone, of which 2 cases were applied early after the monoclonal antibody. Results All three patients were stopped using insulin, blood glucose, C-peptide and urea nitrogen, creatinine were normal after operation; 2 cases of nerve conduction velocity and visual acuity of lower extremity after 3 months after surgery to varying degrees of improvement, has survived 1 6 Months, 10 months, and the other due to liver failure, died at 2 months after surgery. Conclusions Combined pancreas and kidney transplantation is an effective method to treat diabetes with uremia and can improve other complications of diabetes