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[目的]探讨小窝蛋白-1(caveolin-1)和血管内皮生长因子(VEGF)在膀胱尿路上皮癌(BUC)组织中的表达及其临床意义。[方法 ]应用免疫组织化学PV-6000法检测caveolin-1和VEGF在86例BUC和13例正常膀胱黏膜组织中的表达情况并分析其相关性。[结果]Caveolin-1和VEGF蛋白在正常膀胱黏膜呈低表达(8.7%和15.4%),在BUC组织呈高表达(59.6%和75.6%),差异均有统计学意义(P=0.003,P=0.017)。Caveolin-1在BUC组织的阳性表达率随着膀胱癌分级和分期的提高,其表达水平呈增高趋势,差异有统计学意义(P=0.005,P=0.002)。VEGF在BUC组织的阳性表达率随着BUC分级和分期的提高其表达水平亦增高,差异有统计学意义(P=0.006,P=0.002)。Caveolin-1和VEGF蛋白在BUC组织中的阳性表达呈正相关(r=0.245,P=0.023)。[结论]Caveolin-1和VEGF在BUC组织中高表达,可作为促进BUC发生和进展的标志物。
[Objective] To investigate the expression of caveolin-1 and vascular endothelial growth factor (VEGF) in bladder urothelial carcinoma (BUC) and its clinical significance. [Method] The expression of caveolin-1 and VEGF in 86 cases of BUC and 13 cases of normal bladder mucosa was detected by immunohistochemical PV-6000 method and the correlation was analyzed. [Results] The expression of Caveolin-1 and VEGF protein in normal bladder mucosa was low (8.7% vs 15.4%) and high in BUC tissues (59.6% and 75.6% respectively), with statistical significance (P = 0.003, P = 0.017). The positive expression rate of Caveolin-1 in BUC was increased with the grade and stage of bladder cancer, and the expression level of Caveolin-1 showed an increasing trend, the difference was statistically significant (P = 0.005, P = 0.002). The positive expression rate of VEGF in BUC was also increased with the increase of BUC classification and staging, the difference was statistically significant (P = 0.006, P = 0.002). The positive expression of Caveolin-1 and VEGF in BUC tissues was positively correlated (r = 0.245, P = 0.023). [Conclusion] The high expression of Caveolin-1 and VEGF in BUC tissues can be used as a marker to promote the occurrence and progression of BUC.