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经实验证明西红花提取物ＸＨＨ－１的小鼠灌胃ＬＤ５０大于１０ｇ／ｋｇ，毒性很小。ＸＨＨ－１的五个浓度（０．５、１、２、３、４ｍｇ／ｍｌＰＲＰ）均能显著地对抗由ＡＤＰ引起的大鼠体外血小板聚集，并缩短血小板最大聚集时间。ＸＨＨ－１浓度为４、８、１２ｍｇ／ｍｌ时，对ＫＣｌ引起的离体兔主动脉血管平滑肌的抑制作用与对照组相比都有非常显著的统计学意义。大鼠静注１０ｍｇ／ｋｇＸＨＨ－１后１０ｍｉｎ，软脑膜血流量增加５４％，２０ｍｉｎ时仍维持在相近水平，灌胃给药２５０ｍｇ／ｋｇ后３０ｍｉｎ。软脑膜血流量同给药前相比增加了３９％，至６０ｍｉｎ仍维持这一水平，均有显著统计学差异。
Experiments have shown that saffron extract XHH-1 mice fed gavage LD50 greater than 10g/kg, the toxicity is very small. The five concentrations of XHH-1 (0.5, 1, 2, 3, 4 mg/ml PRP) all significantly antagonized the platelet aggregation induced by ADP in vitro and shortened the maximum platelet aggregation time. When the concentration of XHH-1 was 4, 8 and 12 mg/ml, the inhibitory effect of KCl on isolated rabbit aortic vascular smooth muscle was statistically significant compared with the control group. 10 min after intravenous administration of 10 mg/kg XHH-1 in rats, the pial blood flow increased by 54%, and remained at similar levels at 20 min, and it was administered for 30 min after administration of 250 mg/kg. Pial blood flow increased by 39% compared to pre-dose and remained at this level by 60 min, with statistically significant differences.