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目的：探讨一氧化氮（ＮＯ）、内皮素（ＥＴ）与慢性胃炎的关系。方法：分别通过镉还原层析加显色法和放射免疫分析法对４１例慢性胃炎患者和１２例健康人血浆ＮＯ及ＥＴ水平进行了测定。结果：轻度浅表性胃炎组ＮＯ、ＥＴ水平与正常对照组无显著性差异，重度浅表性胃炎组与萎缩性胃炎组ＮＯ、ＥＴ水平均显著高于前两组，幽门螺杆菌（ＨＰ）相关胃炎组二者水平均显著高于非ＨＰ相关胃炎组及正常对照组，非ＨＰ相关胃炎组ＮＯ水平虽高于正常组但无显著性差异，而ＥＴ水平亦显著高于正常组。结论：ＮＯ和ＥＴ参与了慢性胃炎特别是ＨＰ相关性胃炎的病理生理机制。
Objective: To investigate the relationship between nitric oxide (NO), endothelin (ET) and chronic gastritis. Methods: Plasma levels of NO and ET were measured in 41 patients with chronic gastritis and 12 healthy controls by cadmium reduction, colorimetric and radioimmunoassay, respectively. Results: The levels of NO and ET in mild superficial gastritis group were not significantly different from those in normal control group. The levels of NO and ET in severe superficial gastritis group and atrophic gastritis group were significantly higher than those in the former two groups (P < ) Related gastritis group were significantly higher than non-HP-related gastritis group and normal control group, the non-HP-related gastritis group NO levels higher than the normal group but no significant difference, while the ET level was significantly higher than the normal group. Conclusion: NO and ET participate in the pathogenesis of chronic gastritis, especially HP-related gastritis.