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目的探讨卡托普利对心衰患者的疗效及可能机制。方法将入选的66例心力衰竭患者随机分为2组。对照组30例,给予利尿、扩血管等常规抗心衰治疗。ACEI组36例,在常规抗心衰治疗基础上,给予卡托普利100mg/d。用药前及用药后2个月检测EF值及抽取患者晨空腹静脉血检测。结果两组治疗前后血钾、血肌酐变化无统计学意义。ACEI组治疗后CRP下降,EF升高。结论卡托普利可抑制肾素-血管紧张素-醛固酮系统(RAAS)的过度激活,改善心功能。
Objective To investigate the efficacy and possible mechanism of captopril in patients with heart failure. Methods 66 cases of selected heart failure patients were randomly divided into two groups. Control group of 30 cases, given diuretic, vasodilators and other conventional anti-heart failure treatment. In ACEI group, 36 cases received captopril 100 mg / d on the basis of routine anti-heart failure treatment. Before treatment and after 2 months of testing EF value and extraction of fasting venous blood test. Results Before and after treatment, serum potassium and serum creatinine had no statistical significance. ACEI group after treatment decreased CRP, EF increased. Conclusion Captopril can inhibit the over-activation of renin-angiotensin-aldosterone system (RAAS) and improve cardiac function.