顺铂是治疗转移性膀胱肿瘤较为有效的化疗药物之一,在40％病例,可使肿瘤明显缩小。晚近研究发现,动脉灌注顺铂治疗局部浸润性膀胱肿瘤看来很有前途,因为有40％患者痊愈,20％患者好转。这些患者多数以前曾接受放疗,许多已属晚期。动脉灌注化疗的基本原理是比静脉给药有更高的局部峰值浓度,并在浓度——时间曲线下获得更大的面积。药物的全身作用几乎与静脉给药相等,除非药 Cisplatin is one of the more effective chemotherapy drugs for the treatment of metastatic bladder tumors. In 40% of cases, the tumor can be significantly reduced. A recent study found that arterial infusion of cisplatin appears to be promising for the treatment of locally invasive bladder tumors because 40% of patients are cured and 20% of patients are improved. Most of these patients had previously received radiotherapy, many of which were advanced. The rationale for arterial infusion chemotherapy is a higher local peak concentration than intravenous administration and a greater area under the concentration-time curve. The systemic effect of the drug is almost equal to intravenous administration unless the drug is administered