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实验用Ｗｉｓｔａｒ大鼠，分为正常组、低锌组、低锌染镉组、正常染镉组和染镉高锌保护组，分别饲养，其中三组在孕８和１０天注射镉（２．０ｍｇ／ｋｇ）。妊娠第２０天处死动物，取血，并剖腹检查孕鼠内脏和胎鼠畸形情况。研究发现：与正常对照组相比，单纯缺锌即可引起胎鼠的吸收率增高和畸形的发生；而染镉（２．０ｍｇ／ｋｇ）也可引起胎鼠的吸收胎和迟死胎显著增加，并可引起皮下水肿、卷尾等外观畸形。在孕期缺锌的同时，给予孕鼠２．０ｍｇ／ｋｇ体重的镉，孕鼠在整个孕期体重呈负增长，胚胎不能形成；如给予孕鼠高锌饲养（２２７ｍｇ／ｋｇ），胎鼠可得到较好的保护，其吸收胎、死胎率明显下降，存活率显著上升，且胎鼠体重、身长也与对照组相差无几。提示孕鼠缺锌可引发胎儿畸形，缺锌染镉加重胚胎毒作用，而高锌膳食能拮抗镉所造成的胚胎毒作用。
Wistar rats were divided into normal group, low-zinc group, low-zinc-cadmium group, normal cadmium group and high-zinc-cadmium-contaminated group. The three groups were injected with cadmium at 8 and 10 days of gestation. 0 mg / kg). The animals were sacrificed on the 20th day of gestation and the blood was collected. The caesarean section of the pregnant rats and fetal rat malformations were examined by laparotomy. The study found that: compared with the normal control group, simply zinc deficiency can lead to increased fetal fetus absorptivity and malformations; and cadmium (2.0mg / kg) can also cause fetal and fetal mothers fetal fetal and fetal death significantly increased , And can cause subcutaneous edema, volume tail and other appearance deformity. Pregnancy zinc deficiency at the same time, given pregnant rats 2.0mg / kg body weight of cadmium, pregnant rats weight loss during the entire pregnancy negative growth, the embryo can not be formed; given pregnant rats with high zinc feeding (227mg / kg), fetal rats can get more Good protection, its absorption of fetal death rate significantly decreased, the survival rate increased significantly, and fetal rat weight, length and the control group is almost the same. Tip zinc deficiency in pregnant rats can lead to fetal malformations, zinc deficiency with cadmium increased embryotoxicity, and high zinc diet can antagonize the embryonic toxicity caused by cadmium.