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精子顶体蛋白酶为定位在精子顶体膜内部的丝氨酸蛋白酶,涉及很多重要生殖功能,包括精卵相互作用,精子-透明带结合,以及透明带的穿透。在对动物和人的研究中已确定精子顶体蛋白酶在免疫不孕中具有潜在作用,并在不孕的动物中产生特异性抗体。抗体抑制精子顶体蛋白酶活性已在动物和人无法解释的不孕研究中观察到,并已证实精子顶体蛋白酶的胰蛋白酶样酶的活性的免疫学抑制可导致失去穿透透明带。抗体与精子顶体蛋白酶结合,即使不能精确地在活性部位结合,也可通过位向(steric)抑制消除酶接近透明带表面。
Sperm acrosin is a serine protease located within the acrosome of sperm and involves many important reproductive functions including sperm-egg interactions, sperm-zona binding, and zona pellucida penetration. In studies of animals and humans, it has been determined that sperm acrosin has a potential role in immune infertility and that specific antibodies are produced in infertile animals. Antibody inhibition of sperm acrosin activity has been observed in studies of infertility that are unexplained by both animals and humans and has demonstrated that immunological suppression of the activity of tryptic proteases by sperm acrosin can result in the loss of penetrating zona pellucida. Antibodies bind to sperm acrosin and can approach the surface of the zona pellucida via a steric abscess enzyme, even if it does not bind precisely at the active site.