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目的:探讨uPARAP和MMP9在鼻咽癌组织中的表达及其相关性。方法:采用免疫组化SP技术检测58例鼻咽癌组织和30例慢性鼻咽炎组织中uPARAP、MMP9蛋白的表达。结果:鼻咽癌组织中uPARAP、MMP9的阳性表达率分别为75.9%(44/58)、60.3%(35/58);与慢性鼻咽炎比较,uPARAP、MMP9在鼻咽癌中的阳性表达显著增高(P<0.05);鼻咽癌中uPARAP、MMP9的表达与肿瘤的病理分级、临床分期密切相关(P<0.05)。鼻咽癌组织中uPARAP表达与MMP9的表达水平呈明显正相关(P<0.05)。结论:uPARAP、MMP9在鼻咽癌的侵袭转移过程可能起重要作用。
Objective: To investigate the expression and correlation of uPARAP and MMP9 in nasopharyngeal carcinoma. Methods: The expressions of uPARAP and MMP9 in 58 cases of nasopharyngeal carcinoma and 30 cases of chronic nasopharyngitis were detected by SP immunohistochemistry. Results: The positive rates of uPARAP and MMP9 in nasopharyngeal carcinoma were 75.9% (44/58) and 60.3% (35/58), respectively. Compared with chronic nasopharyngitis, the positive rates of uPARAP and MMP9 were significantly higher in NPC (P <0.05). The expression of uPARAP and MMP9 in nasopharyngeal carcinoma was closely related to the pathological grade and clinical stage (P <0.05). The expression of uPARAP in nasopharyngeal carcinoma tissues was positively correlated with the expression of MMP9 (P <0.05). Conclusion: uPARAP and MMP9 may play an important role in the invasion and metastasis of nasopharyngeal carcinoma.