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目的 妊高宁Ⅱ号治疗妊高征的实验研究及疗效.方法 将60只Wistar孕鼠随机分5组,50只采用肾外包扎法建立妊高征动物模型,分别给药治疗,测各组孕鼠血压、血栓素(TXB_2)及6-酮-前列腺素F_(1α)(6-K-PGF_(1α))含量.结果 妊高宁Ⅱ号高剂量组与西药对照组及正常孕鼠血压无显著差异,妊高宁Ⅱ号对孕鼠血清6-酮-前列腺素F_(1α)有提高作用,优于西药组;妊高宁Ⅱ号高剂量组和西药对照组对血栓素(TXB_2)均有降低作用.结论 妊高宁Ⅱ号对妊高征有良好治疗作用,并证实了妊高征的病因学说.
Objective To study the therapeutic effect and therapeutic effect of Shenhuaning II on the treatment of pregnancy-induced hypertension.Methods Sixty Wistar pregnant mice were randomly divided into 5 groups, and 50 animal models of pregnancy-induced hypertension were established by using the renal plugging method. Blood pressure, thromboxane (TXB_2) and 6-keto-prostaglandin F_(1α) (6-K-PGF_(1α)) levels in pregnant rats. Results High blood pressure in the Pregnancy-Growing II group and Western medicine control group and normal pregnant rats There was no significant difference between the two groups. Pregnancy-induced hyperglycemia in serum of 6-keto-prostaglandin F_(1α) in pregnant mice was better than that in western medicine group; Xueshuaoning II high-dose group and western medicine control group in thromboxane (TXB_2) All have a reduced effect. Conclusions: PIHII has a good therapeutic effect on PIH and confirms the etiology of PIH.