论文部分内容阅读
目的 研究脑梗死患者纤维蛋白单体聚合功能与梗死体积和神经功能缺损程度的关系 ,并探讨其临床意义。方法 将 82例脑梗死患者依据不同的梗死体积分为小梗死组、中梗死组和大梗死组 ;依据临床神经功能缺损程度评分标准 ,分为轻、中、重三型 ,检测患者纤维蛋白单体聚合功能参数 ,设立 5 0例健康人为对照组。结果 脑梗死患者纤维蛋白单体聚合功能各项参数均较健康人显著增高。不同梗死体积组中 ,大梗死组纤维蛋白单体聚合速率 (FMPV)较小梗死组和中梗死组显著增高 ;不同程度神经功能缺损组中 ,重度缺损组FMPV和分子功能参数较轻度缺损组显著增高 ,中度缺损组FMPV较轻度缺损组显著增高。脑梗死患者神经功能缺损程度评分与纤维蛋白聚合功能各项参数呈不同程度的正相关。结论 纤维蛋白单体聚合功能测定不仅能全面地反映纤维蛋白原 (Fbg)的质量状态 ,而且与脑梗死的病情密切相关 ,纤维蛋白单体聚合功能参数 ,特别是FMPV的增加可能反映病情严重程度 ,对患者病情的临床评价具有一定的意义。
Objective To study the relationship between the aggregation function of fibrin monomers and infarct volume and neurological deficit in patients with cerebral infarction and to explore its clinical significance. Methods 82 patients with cerebral infarction were divided into small infarction group, middle infarction group and large infarction group according to different infarct volume. According to clinical neurological deficit score, the patients were divided into mild, moderate and severe types, Body polymerization parameters, the establishment of 50 healthy controls for the control group. Results The parameters of fibrin monomer polymerization in patients with cerebral infarction were significantly higher than those in healthy subjects. In different infarct volume groups, FMPV increased significantly in infarct group and middle infarct group. In different degrees of neurological deficit group, FMPV and molecular function parameters in severe defect group were lower than those in mild defect group Was significantly higher, moderate impairment group FMPV was significantly higher than the mild defect group. The scores of neurological impairment in patients with cerebral infarction were positively correlated with various parameters of fibrin polymerization. Conclusion The measurement of fibrin monomer polymerization not only fully reflects the quality status of fibrinogen (Fbg), but also is closely related to the severity of cerebral infarction. The functional parameters of fibrin monomer polymerization, especially the increase of FMPV may reflect the severity of illness , The clinical evaluation of the patient’s condition has a certain significance.