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目的:观察厄贝沙坦联合大黄虫丸对早期糖尿病肾病的临床疗效。方法:将64例早期糖尿病肾病患者随机分为对照组30例和治疗组34例。对照组予常规治疗加厄贝沙坦口服,治疗组在对照组基础上加服大黄虫丸治疗;2组疗程均为3个月,比较临床疗效。结果:总有效率治疗组为88.2%,对照组为73.3%,2组比较,差异有统计学意义(P<0.05);治疗后24h尿蛋白(24h UP)、尿微量白蛋白(m ALB)、尿白蛋白排泄率(UAER)、血肌酐(Scr)、血尿素氮(BUN)改善治疗组均优于对照组(P<0.05)。结论:厄贝沙坦联合大黄虫丸治疗早期糖尿病肾病临床疗效显著。
Objective: To observe the clinical efficacy of irbesartan combined with rhubarb Zhechong pill on early diabetic nephropathy. Methods: 64 patients with early diabetic nephropathy were randomly divided into control group (n = 30) and treatment group (n = 34). The control group was given conventional treatment plus irbesartan orally, and the treatment group was given Dahuang Zhechong pill on the basis of the control group. The two courses of treatment were 3 months, and the clinical curative effect was compared. Results: The total effective rate was 88.2% in the treatment group and 73.3% in the control group. There was a significant difference between the two groups (P <0.05). After 24 h of treatment, the urinary protein (24h UP), urinary albumin (ALB) , Urinary albumin excretion rate (UAER), serum creatinine (Scr) and blood urea nitrogen (BUN) were significantly improved in the treatment group compared with the control group (P <0.05). Conclusion: Irbesartan combined with rhubarb Zhechong pill in the treatment of early diabetic nephropathy clinical efficacy significantly.