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血胆固醇过多是以血浆总胆固醇和 LDL胆固醇增高为特征的一组多病因脂质代谢紊乱。胆固醇由两种来源进入体内代谢池:从饮食中吸收约300～500mg/d 或内源性生物合成700～900mg/d。罗伐他了(lovastatin)降低原发性高胆固醇血症患者总胆固醇和 LDL胆固醇。有报道新霉素、表面活性剂、蔗糖聚酯和植物甾醇能限制胆固醇吸收进入肠腔粘膜细胞。
Hypercholesterolemia is a group of multiple-cause lipid metabolism disorders characterized by increased plasma total cholesterol and LDL cholesterol. Cholesterol enters the body’s metabolic pool from two sources: about 300-500 mg / d from the diet or 700-900 mg / d of endogenous biosynthesis. Lovastatin reduces total cholesterol and LDL cholesterol in patients with primary hypercholesterolemia. It has been reported that neomycin, surfactants, sucrose polyesters and phytosterols can limit cholesterol absorption into the intestinal mucosal cells.