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中心体是动物细胞有丝分裂期微管组织中心,对于细胞有丝分裂期形成纺锤体、正常分裂及染色体精确分离至关重要.中心体失调控常造成遗传物质错误分配,最终诱发肿瘤形成.因此,对中心体结构及数量的精密调控将对细胞命运起着决定作用.目前发现,中心体至少包含100多种调节蛋白,这些蛋白在细胞内的功能各异.最近很多研究显示,多种DNA损伤修复及应答通路的激酶或磷酸酶定位于中心体,并且参与中心体调控.本文将对中心体结构、中心体复制、中心体分离、中心体扩增、DNA损伤与中心体异常及DNA损伤反应性蛋白在中心体调控中的功能作一综述.
Centrosome is the center of mitotic microtubule organization of animal cells, which is crucial for mitotic cell formation, normal division and accurate chromosome segregation.Central body dysregulation often results in misdistribution of genetic material and eventually induces tumor formation.Therefore, The precise regulation of body structure and quantity will play a decisive role in the fate of cells.Currently, the centrosome contains at least 100 kinds of regulatory proteins, which have different functions in the cell.Recent studies have shown that a variety of DNA damage repair and The kinases or phosphatases of the response pathway are located in the centrosome and are involved in the regulation of the centrosome.In this paper, the structure of the centrosome, centrosome replication, centrosome separation, centrosome amplification, DNA damage and centrosome abnormalities, and DNA damage-responsive proteins The functions of central body regulation are reviewed.