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目的探讨母体叶酸及亚甲基四氢叶酸还原酶(MTHFR)基因多态性与低出生体质量儿的关系。方法收集早产儿母体血标本70例为观察组,同期产科收治的正常出生儿母体血标本70例为对照组,检测2组叶酸含量及MTHFR C677T基因类型。结果 140例母体血清MTHFR(C677T)基因检测显示野生型基因占比20.71%(29/140),杂合突变型占比48.57(68/140),纯合突变型占比30.71%(43/140)。观察组叶酸含量(23.22±0.23)ng/mL,对照组叶酸含量(17.23±0.17)ng/mL,2组比较差异有统计学意义(P<0.05)。结论叶酸补充要个体化,补充过多或过少均可增加低出生体质量儿出生风险。
Objective To explore the relationship between maternal folic acid and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and low birth weight children. Methods Seventy patients with maternal blood samples from preterm infants were selected as the observation group. 70 maternal blood samples from obstetric subjects during the same period were collected as the control group. The folic acid levels and MTHFR C677T genotypes were detected in two groups. Results The MTHFR (C677T) gene in 140 maternal serum samples showed that the wild type gene accounted for 20.71% (29/140), the heterozygous mutation accounted for 48.57 (68/140), and the homozygous mutant accounted for 30.71% (43/140) ). The content of folic acid in the observation group was (23.22 ± 0.23) ng / mL, and that in the control group was (17.23 ± 0.17) ng / mL. The difference between the two groups was statistically significant (P <0.05). Conclusion Folic acid supplementation to be individualized, too much or too little supplement can increase the risk of birth of low birth weight children.