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目的 :评估垂体瘤增殖细胞的核抗原 (PCNA)指数及其临床病理特征作为预测其复发标志物的实用性。方法 :采用免疫组织化学LSAB法检测 33例垂体瘤 (其中复发组 1 5例 ,非复发组 1 8例 )的增殖指数 ,并结合其临床特征进行分析。结果 :垂体瘤PCNA指数随肿瘤体积增大而增高 ,复发组PCNA指数高于非复发组 (P <0 0 1 ) ,而同一病人复发肿瘤较初发肿瘤的PCNA指数增高 (P <0 0 5)。逐步多元回归分析显示垂体瘤术后复发的相关因素包括①高PCNA指数 ;②大腺瘤 ;③鞍外生长 ;④不全切除。结论 :PCNA指数可作为判断垂体瘤预后的指标之一
PURPOSE: To evaluate the clinical significance of proliferating cell nuclear antigen (PCNA) index and its clinicopathological features as predictors of its recurrence markers. Methods: The proliferation index of 33 cases of pituitary adenoma (including 15 cases of recurrence group and 18 cases of non-recurrence group) was detected by immunohistochemical LSAB method and analyzed with the clinical features. Results: The PCNA index of pituitary tumor increased with the increase of tumor volume. The PCNA index of recurrence group was higher than that of non-recurrence group (P <0.01), while the PCNA index of recurrent tumor of the same patient was higher than that of primary tumor (P <0.05) ). Stepwise multiple regression analysis showed that recurrence of pituitary tumor related factors include ① high PCNA index; ② large adenoma; ③ saddle outside the growth; ④ incomplete resection. Conclusion: PCNA index can be used as one of the prognostic indicators of pituitary tumors