缝隙连接(GJ)是细胞间通道,是由许多连接蛋白亚型组成的中空通道,它能使相邻的细胞胞质相通,在维持细胞的正常功能中起着重要的作用,其在癫痫的形成和发展过程中也发挥重要的作用。不同的组织表达不同的连接蛋白,连接蛋白亚型基因剔除会影响癫痫动物模型的惊厥发作,缝隙连接的阻滞剂有抗惊厥作用。缝隙连接在癫痫发病机制的作用有待于进一步研究,缝隙连接的特异性抑制剂有可能成为治疗癫痫的新方法,为癫痫的治疗提供新的思路。 Gap junctions (GJs) are intercellular channels, which are hollow channels composed of many connexin subtypes. They can make adjacent cells cytoplasm communicate and play an important role in maintaining the normal function of cells. In GJ, The formation and development process also plays an important role. Different tissues express different connexin, knockout of connexin subtypes can affect seizures in animal models of epilepsy, and gap junction blockers have anticonvulsant effect. The role of gap junction in the pathogenesis of epilepsy remains to be further studied. The specific inhibitor of gap junction may become a new method to treat epilepsy and provide a new idea for the treatment of epilepsy.