论文部分内容阅读
目的总结新鲜冰冻血浆在极低出生体重早产儿的临床疗效。方法 2013年1月至2015年11月临夏州人民医院新生儿科收治住院的早产儿162例。2013年1月至2014年1月的住院患儿72例为对照组;2014年2月至2015年11月的住院患儿90例为观察组。对照组给予维持血糖、预防感染、促肺成熟、合理的喂养等常规治疗;观察组在基础治疗的同时给予新鲜冰冻血浆静脉输注10~15mL/kg,3~7次。观察其发生感染、脏器出血、喂养不耐受、低血糖、多器官功能衰竭情况及光疗时间、住院时间、死亡率。结果观察组感染、脏器出血、喂养不耐受、低血糖、多器官功能衰竭发生率及死亡率均低于对照组,差异有统计学意义(P<0.05)。观察组光疗时间及住院时间均低于对照组,差异有统计学意义(P<0.05)。结论使用新鲜冰冻血浆治疗极低体重早产儿可减少脏器出血情况、感染、喂养不耐受、低血糖、多器官功能衰竭等的发生率。同时观察组患儿随访未见输血相关性传染病的发生,安全有效。
Objective To summarize the clinical efficacy of fresh frozen plasma in very low birth weight preterm infants. Methods From January 2013 to November 2015, 162 cases of premature infants admitted to neonatology department of Linxia People’s Hospital were enrolled. 72 hospitalized children from January 2013 to January 2014 were the control group; 90 hospitalized children from February 2014 to November 2015 were the observation group. The control group was given conventional therapy of maintaining blood sugar, preventing infection, promoting lung ripening and reasonable feeding. In the observation group, fresh frozen plasma was infused intravenously 10 ~ 15mL / kg, 3 ~ 7 times while basic treatment was given. Observe the infection, organ bleeding, feeding intolerance, hypoglycemia, multiple organ failure and phototherapy time, hospital stay, mortality. Results The incidence of infection, organ bleeding, feeding intolerance, hypoglycemia, multiple organ failure and mortality in observation group were lower than those in control group (P <0.05). The observation group’s phototherapy time and hospitalization time were lower than the control group, the difference was statistically significant (P <0.05). Conclusion The use of fresh frozen plasma in the treatment of very low birth weight preterm infants can reduce the incidence of organ bleeding, infection, feeding intolerance, hypoglycemia, multiple organ failure and so on. At the same time, there was no transfusion-related infectious disease in follow-up observation group, safe and effective.