本文报告新生儿大肠杆菌脑膜炎为经脑脊液培养证实大肠杆菌引起的化脓性脑膜炎。患儿表现为体温低、或发热、嗜睡、前囟饱满、惊厥、皮肤与巩膜黄染等。见于未成熟儿与成熟儿。常有羊膜早破、胎儿宫内窘迫、急产或臀位产。免疫球蛋白测定IgA、IgM、IgG均降低。头孢噻肟钠治疗有效。 This article reports that neonatal E. coli meningitis was purified by cerebrospinal fluid to confirm purulent meningitis caused by E. coli. Children showed low body temperature, or fever, lethargy, full bregma, convulsions, skin and scleral yellow dye. Found in immature children and mature children. Often amniotic premature rupture, fetal distress, urgency or breech birth. Immunoglobulin determination of IgA, IgM, IgG were reduced. Cefotaxime sodium treatment is effective.