论文部分内容阅读
肿瘤标记是指血液或其他体液中可测定的患肿瘤时升高的物质,测定肿瘤标记可发现肿瘤,提示肿瘤特异性,观察肿瘤病程,对病程监控特别是疗效判断和肿瘤复发的意义是公认的。但是婴儿和儿童在生理情况下和许多良性疾病时肿瘤标记物也可升高,因此其临床意义有限。 临床上仅肿瘤标记值升高而无相关形态学改变的证据是不能诊断肿瘤的。当诊断明确的肿瘤,其部位和肿瘤标记升高有很大程度相关性,例如诊断神经母细胞瘤时,24h尿儿茶酚胺代谢产物增高,同时B超证实为肾上腺肿瘤。
Tumor marker refers to the blood or other body fluids can be measured when the tumor is elevated substances, tumor markers can be found in the determination of tumor, suggesting tumor specificity, the observation of tumor progression, the course of disease monitoring, especially in the judgment of efficacy and tumor recurrence is recognized of. However, infants and children may also have increased tumor markers in physiological conditions and in many benign conditions, and thus their clinical significance is limited. Evidence that clinically only elevated tumor marker values without associated morphological changes can not diagnose tumors. When a well-defined tumor is detected, its location is strongly correlated with an increase in tumor markers. For example, urinary catecholamine metabolites increased 24 h after diagnosis of neuroblastoma and B-adrenal tumors were confirmed.