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原发性高血压(EH)是心脑血管疾病发病和死亡的重要危险因素。近年来,国内外许多学者针对高血压肾病与心血管事件发生危险的相关性进行了一系列的实验研究。大量证据显示,肾小球滤过率、尿微量白蛋白是高血压肾病的早期标志,也是高血压患者心血管事件发病率和致死率的独立危险因素。最近的研究显示,脉压差的升高与原发性高血压患者肾功能受损独立相关。
Essential hypertension (EH) is an important risk factor for the onset and death of cardiovascular and cerebrovascular diseases. In recent years, many scholars at home and abroad have carried out a series of experimental studies on the correlation between the risk of hypertensive nephropathy and cardiovascular events. There is ample evidence that glomerular filtration rate and urinary microalbumin are early markers of hypertensive nephropathy and are independent risk factors for cardiovascular morbidity and mortality in hypertensive patients. Recent studies have shown that elevated pulse pressure is independently associated with impaired renal function in patients with essential hypertension.