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目的:评价肿瘤标志物肿瘤特异性生长因子(TSGF)、血清糖抗原19-9(CA19-9)、血清糖抗原125(CA125)对消化道恶性肿瘤的诊断价值,以及联合检测的临床意义。方法:受检者包括消化道肿瘤患者102例,其中肝癌31例,胃癌27例,食管癌16例,结直肠癌17例,胰腺癌11例。消化系良性疾病患者57例,其中肝硬化23例,良性非肝病34例。健康查体20例。联合检测TSGF、CA19-9、CA125。结果:消化道恶性肿瘤患者的TSGF、CA19-9、CA125水平高于肝硬化组(TSGF除外)、非肝病组及健康组(P<0.01)。上述3指标对消化道肿瘤诊断的敏感性分别为69.6%、58.8%、53.9%。三者联合检测对消化道恶性肿瘤诊断的敏感性可提高为92.2%。结论:TSGF、CA19-9、CA125均为较好的消化道恶性肿瘤标志物,联合检测效果更佳。
OBJECTIVE: To evaluate the diagnostic value of tumor markers of tumor-specific growth factor (TSGF), serum carbohydrate antigen 19-9 (CA19-9) and serum carbohydrate antigen 125 (CA125) in gastrointestinal malignancies and their clinical significance. Methods: The subjects included 102 patients with gastrointestinal cancer, including 31 cases of liver cancer, 27 cases of gastric cancer, 16 cases of esophageal cancer, 17 cases of colorectal cancer and 11 cases of pancreatic cancer. 57 cases of patients with benign digestive diseases, including 23 cases of cirrhosis, benign non-liver disease in 34 cases. 20 cases of physical examination. Joint detection of TSGF, CA19-9, CA125. Results: The levels of TSGF, CA19-9 and CA125 in patients with gastrointestinal cancer were significantly higher than those in patients with cirrhosis (except TSGF), non-liver disease group and healthy group (P <0.01). The sensitivity of the above three indexes to the diagnosis of digestive tract tumors were 69.6%, 58.8% and 53.9% respectively. The three combined detection of digestive tract cancer diagnosis sensitivity can be increased to 92.2%. Conclusion: TSGF, CA19-9 and CA125 are all good markers of gastrointestinal cancer, and the combined detection is better.