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为了评价异环磷酰胺、美斯纳、阿霉素和５氟脲嘧啶（ＩＭＡＦ方案）联合治疗复发转移性乳腺癌的疗效，对乳腺癌根治术后接受常规ＣＭＦ辅助化疗和（或）放疗后，在２ａ内出现复发转移的２６例患者应用ＩＭＡＦ方案化疗。结果完全缓解４例（１５．４％），部分缓解１２例（４６．２％），总有效率为６１．５％（１６／２６）。毒副反应主要为恶心、呕吐、骨髓抑制、脱发和镜下血尿。结果表明ＩＭＡＦ方案是治疗复发转移性乳腺癌疗效较好的方案。
To evaluate the efficacy of ifosfamide, Meissner, Adriamycin, and 5-fluorouracil (IMAF) in the treatment of recurrent metastatic breast cancer, conventional CMF adjuvant chemotherapy and/or radiation therapy were performed after radical mastectomy Later, 26 patients with recurrence and metastasis within 2 years were treated with IMAF chemotherapy. The results were complete remission in 4 patients (15.4%), partial remission in 12 patients (46.2%), and the total effective rate was 61.5% (16/26). The main toxicities were nausea, vomiting, bone marrow suppression, hair loss and microscopic hematuria. The results show that the IMAF program is a better treatment for recurrent metastatic breast cancer.