英国伦敦Hammersmith医院的D’Souza AL及其同事在《英国医学杂志》上发表文章称,益生菌(probiotics)可用于预防抗生素相关性腹泻。 为了评价益生菌在预防和治疗抗生素使用相关性腹泻中的有效性,研究者对1966-2000年间Medline和Cochrane图书馆检索得到的9项随机、双盲、安慰剂对照的益生菌试验进行了荟萃研究。其中2个试验考察了益生菌在儿童中的效果,4个试验使用的是酵母(Saccharomyces boulardii),4个试验用的是乳酸杆菌,1个试验用的是产生乳酸的肠球菌菌株。3个试验是多个菌 D’Souza AL and colleagues at Hammersmith Hospital in London, UK, in an article in the British Medical Journal, said probiotics can be used to prevent antibiotic-associated diarrhea. To assess the effectiveness of probiotics in the prevention and treatment of antibiotic-associated diarrhea, the researchers conducted a meta-analysis of nine randomized, double-blind, placebo-controlled probiotic tests retrieved from Medline and the Cochrane Library from 1966 to 2000 the study. Two of the trials examined the effect of probiotics in children, four used Saccharomyces boulardii, four used Lactobacilli, and one used lactate-producing Enterococcus strains. Three experiments were multiple bacteria