大环内酯类抗生素在临床上的广泛应用取得了良好的疗效,但随着该类药物临床应用的增加,细菌对其耐药性也不断上升。近年来,世界先进国家加快了对其构效关系的研究,开发出对耐药菌有效的酮内酯类药物,如泰利霉素等。本文对酮内酯类药物的开发、市场机遇等情况作一介绍。 Macrolide antibiotics in clinical widely used has achieved good results, but with the clinical application of such drugs increased bacterial resistance to it is also rising. In recent years, advanced countries in the world have accelerated their studies on the structure-activity relationship and developed ketolides, such as telithromycin, which are effective against resistant bacteria. In this paper, the development of ketolide drugs, market opportunities and other conditions to make an introduction.