Ghrelin是一种由28个氨基酸组成的内源性促生长激素释放肽,其在体内的组织中广泛存在,其与生长激素促分泌物质受体(GHSR)各亚型结合后,不仅能有效地促进生长激素分泌,还能调节内分泌、促进摄食、增加体重、维持能量代谢正平衡、改善恶病质,以及降低血管抵抗、改善血流动力学、抗细胞凋亡,故ghrelin可能从多层次多角度逆转心衰的病理生理过程。 Ghrelin is an endogenous ghrelin consisting of 28 amino acids. It is widely found in the tissues of the body and binds to the GHSR subtypes not only efficiently Ghrelin may promote multi-level reversal of growth hormone secretion, regulate endocrine, promote feeding, increase body weight, maintain positive balance of energy metabolism, improve cachexia, reduce vascular resistance and improve hemodynamics and anti-apoptosis Pathophysiology of heart failure.