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目的 探讨胰岛素抵抗在高血压并发脑梗死患者的左心室肥厚形成中的作用。方法 测定 2 1例脑梗死 ,13例脑梗死合并左心室肥厚患者口服葡萄糖耐量试验后血糖、血胰岛素变化和左心室质量 ,并作相关分析。结果 合并左心室肥厚的脑梗死患者血糖、血胰岛素升高 ,胰岛素敏感指数降低 ,其餐后 1h血糖、空腹胰岛素和左心室质量呈正相关 (r =0 0 1,0 83 ,P <0 0 5 )。结论 脑梗死患者的胰岛素抵抗与其左心室肥厚呈正相关 ,提示胰岛素抵抗参与了脑梗死左心室肥厚形成 ,其机制有待进一步研究。
Objective To investigate the role of insulin resistance in the development of left ventricular hypertrophy in hypertensive patients with cerebral infarction. Methods Blood glucose, blood insulin and left ventricular mass were measured after oral glucose tolerance test in 21 patients with cerebral infarction and 13 patients with cerebral infarction and left ventricular hypertrophy. The correlations were analyzed. Results The levels of blood glucose, insulin and insulin sensitivity were decreased in patients with left ventricular hypertrophy complicated by left ventricular hypertrophy. The postprandial blood glucose, fasting insulin and left ventricular mass were positively correlated at 1 hour (r = 0 0 1, 0 83, P 0 05 ). Conclusions Insulin resistance in patients with cerebral infarction is positively correlated with left ventricular hypertrophy, suggesting that insulin resistance is involved in the development of left ventricular hypertrophy in patients with cerebral infarction. The mechanism remains to be further studied.