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(一)杜米生(Dormison) 人类在上古时代就知曉酒精具有催眠作用。此后在研究醇的催眠作用后,發現其催眠疗效依次为叔醇>仲醇>伯醇。对伯醇来講,具有最好疗效的一般含有6—8个碳原子。具有支鏈者,其催眠作用較小。同时發現醇的不飽和性也能加深其催眠疗效。自从1890年左右第一个醇性催眠剂即叔戊醇問世后,此后就对醇类催眼疗效的研究日趋冷淡,直至1951年Margolin-等氏才發表3-甲基-戊炔基-醇-3(3-Methylpentyne-ol-3)的催眠疗效。这是一种屬中时作用的新催眠剂。商業名称为杜米生(Dormison),为液体,沸点121.5℃(亦有报道119°—121℃者),化学結構为:
(1) Dormison Humans knew that alcohol had a hypnotic effect in ancient times. After studying the hypnotic effect of alcohol, the hypnotic efficacy was found to be tertiary alcohol> secondary alcohol> primary alcohol. For primary alcohols, the best effect usually contains 6-8 carbon atoms. With a branch, the hypnotic effect is small. At the same time, it was found that the unsaturation of alcohol can also deepen its hypnotic efficacy. Since the introduction of tert-amyl alcohol, the first alcoholic hypnotic agent, around 1890, the research on the alcohol-boosting effects of alcohols has become increasingly cold until 1951, when Margolin-Pt et al published 3-methyl-pentynyl-alcohol- Hypnotic effect of 3-(3-Methylpentyne-ol-3). This is a new hypnotic agent that is moderately active. The commercial name is Dormison, which is a liquid and has a boiling point of 121.5°C (a report of 119°-121°C is also available). The chemical structure is: