论文部分内容阅读
许多研究证明:血清高密度脂蛋白—胆固醇(HDL—C)与动脉粥样硬化之间呈显著负相关。即血清 HDL—C 浓度升高,动脉粥样硬化发病率下降。因此,血清 HDL—C 已被公认为抗动脉粥样硬化因子,其机理主要是:HDL—C 能将周围细胞多余的胆固醇转运到肝脏降解并且 HDL 能竞争的与低密度脂蛋白受体结合,使 LDL 进入细胞减少,起到防止细胞内胆固醇大量堆积的作用。许多因素:如高血脂、吸烟、饮酒、体力活动减少、性别年龄及某些药物可在不同程度上影响 HDL—C含量,并很有可能通过该途径对冠心病的发生产生作用.
Many studies have shown that there is a significant negative correlation between serum high-density lipoprotein-cholesterol (HDL-C) and atherosclerosis. Serum HDL-C concentration increased, the incidence of atherosclerosis decreased. Therefore, the serum HDL-C has been recognized as anti-atherosclerotic factors, its mechanism is mainly: HDL-C can peripheral cells of excess cholesterol transport to liver degradation and HDL competing with low density lipoprotein receptor binding, LDL into the cells to reduce, play a role in preventing the accumulation of large amounts of intracellular cholesterol. Many factors such as hyperlipidemia, smoking, alcohol consumption, decreased physical activity, sex and age, and certain drugs can affect HDL-C content to varying degrees and may have an effect on the occurrence of coronary heart disease through this pathway.