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目的探究改良式异体皮加自体微粒皮移植治疗大面积烧伤的临床应用效果和安全性。方法从2012年3月—2014年6月金华市中心医院烧伤科接诊病例中抽取的110例大面积烧伤病例作为研究对象。将110例病例随机均分为治疗组和观察组2个研究组,对治疗组的病例进行改良式异体皮加自体微粒皮移植治疗;对观察组的病例进行传统的邮票植皮治疗。观察分析2组病例的移植皮片在治疗后的异体皮成活率、皮片融合时间、全身创面愈合时间、住院时间、1%烧伤面积的治疗费用、创面感染率、并发症发生率、体温变化等。结果治疗后,治疗组的异体皮成活率、皮片融合时间、全身创面愈合时间、1%烧伤面积的治疗费用、创面感染率及并发症发生率较观察组下降明显(P<0.05),2组病例的体温变化、住院时间差异无统计学意义(P>0.05)。结论改良式异体皮加自体微粒皮移植治疗大面积烧伤效果显著,从一定程度上还减少了创面感染和并发症的发生,安全性高,同时减少了病患的治疗费用,值得在临床应用中大力推广和使用。
Objective To investigate the clinical effect and safety of modified allogenic skin autograft skin grafting in treating large area burn. Methods From March 2012 to June 2014, 110 cases of extensive burns in Jinhua Central Hospital admitted from burn department were selected as research objects. 110 cases were randomly divided into treatment group and observation group two study groups, the treatment group of patients with modified allogene plus autologous skin graft; the observation group of patients underwent traditional stamp grafting. The skin allograft survival rate, skin fusion time, total wound healing time, hospitalization time, treatment cost of 1% burns area, wound infection rate, complication rate, body temperature change Wait. Results After treatment, allogeneic skin survival rate, skin fusion time, total wound healing time, treatment cost of 1% burn area, wound infection rate and complication rate in treatment group were significantly lower than those in observation group (P <0.05); 2 There was no significant difference in body temperature and hospital stay between the two groups (P> 0.05). Conclusion Modified allogene skin autograft transplantation of autologous skin grafts for the treatment of large area burn significantly, to a certain extent, reduce the incidence of wound infection and complications, high safety, and reduce the cost of treatment of patients, it is worth in clinical application Vigorously promote and use.