胃癌的发病率和病死率在全球范围内高居不下，其发生和发展是一个多因素、多环节的复杂病理过程。幽门螺杆菌（ Hp）作为胃癌独立的危险因素已众所周知，根除Hp可显著减少胃癌的发生。但随着研究的深入，国内研究者发现，Hp在不利于自身生长的环境中会发生变异而形成更难根除的幽门螺杆菌L型（ Hp－L），Hp－L与胃癌的发生、发展关系密切。“,”The morbidity and mortality of gastric cancer remain high worldwide .Its occurrence and development is a multi-factor,multi-link complex pathological process.Helicobacter pylori(Hp) has been known as a single dangerous factors of gastric cancer,and Hp eradication could be an effective approach to decrease onset of gastric cancer.But with more in-depth discussion,the researchers found that under some hostile conditions,Hp might change from vegetative forms into Hp L-form( Hp-L) ,which is more difficult to eradicate,was and is closely with the development of gastric cancer.