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目的:观察经颅磁刺激抑制右侧初级运动皮质(M1)后双侧中央前回精细分区有效连接变化情况。方法:选取21例健康志愿者纳入本研究，于持续短阵脉冲刺激(cTBS)干预前、后分别行静息态功能磁共振(rs-fMRI)检查，参照中科院自动化研究所制订的脑图谱对受试者双侧中央前回进行精细分区，选用Granger因果分析观察受试者双侧中央前回有效连接变化情况。结果:经cTBS抑制右侧M1区后受试者双侧中央前回各亚区有效连接呈显著变化，右上肢功能区对左上肢、左头面部功能区的有效连接减弱，左上肢功能区对右侧头面部及右上肢功能区的有效连接增强。结论:经cTBS抑制右侧M1区后，受试者双侧M1区上肢功能区的有效连接变化反映了半球间交互抑制，同时M1躯干功能区也发生了与上肢功能区方向相反的有效连接改变。“,”Objective:To investigate any change in the effective connectivity between the bilateral anterior central gyruses after transcranial magnetic stimulation (TMS).Methods:Twenty-one healthy subjects were examined using resting state functional magnetic resonance imaging (rs-fMRI) before and after receiving continuous theta burst stimulation (cTBS). The brain atlas of the Institute of Automation of the Chinese Academy of Sciences was used for fine partitioning of the bilateral anterior central gyruses. Granger causality analysis was used to compare any changes in the effective connectivity between them.Results:After the cTBS inhibited the right M1 area, significant changes in effective connectivity among the sub-regions of the bilateral M1 area were observed. The effective connectivity of the right upper limb to the left upper limb and the left head to face were weakened, while that of the left upper limb to the right head, as well as of the face to the right upper limb was enhanced.Conclusion:For people whose right M1 area has been inhibited by cTBS, the effective connectivity changes in both upper limb functional areas of the M1 region reflect inter-hemispheric inhibition. Opposite changes were found in the trunk and upper limbs.