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肺损伤纤维化是一个复杂的病理生理过程,近年来研究表明许多细胞因子参与了其反应,其中γ-干扰素(IFN-γ)是一类由活化的淋巴细胞分泌的在宿主防御系统中起重要作用的细胞因子。IFN-γ在肺损伤纤维化的病理过程中表达增加,并和白细胞介素-12、肿瘤坏死因子-α、白细胞介素-13、转化生长因子-β、结缔组织生长因子有相互调节作用。IFN-γ通过与细胞因子的相互作用抑制促纤维化细胞因子(转化生长因子-β及结缔组织生长因子)的表达、抑制细胞外基质的沉积而在肺及肺外器官中发挥其抗纤维化作用,本文就这方面的研究进展作一概述。
Pulmonary Injury Fibrosis is a complex pathophysiological process. In recent years, studies have shown that many cytokines are involved in the response. Among them, IFN-γ is a type of protein secreted by activated lymphocytes in the host defense system Important role of cytokines. The expression of IFN-γ is increased during the pathological process of lung injury induced by fibrotic fibrosis and interacts with interleukin-12, tumor necrosis factor-α, interleukin-13, transforming growth factor-β and connective tissue growth factor. IFN-γ exerts its anti-fibrosis in the lungs and extra-pulmonary organs by inhibiting the expression of the pro-fibrotic cytokines (transforming growth factor-β and connective tissue growth factor) by interacting with cytokines, inhibiting the deposition of extracellular matrix This article gives an overview of the research progress in this field.