论文部分内容阅读
目的探讨甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)、甲状腺受体抗体(TRAb)与格雷夫斯眼病(GO)的关系,了解各指标在GO患者发病中的作用。方法采用放射免疫分析法检测64例格雷夫斯病(GD)患者及121例GO患者血清TGAb、TMAb、TRAb值,并对两组各指标的检测值及TRAb阳性检出率进行比较。结果两组患者血清TGAb、TMAb活性差异无统计学意义(P>0.05);GO组及GD组TRAb活性分别为(28±6)U/L和(11±10)U/L,GO组明显高于GD组(P<0.05);GO组及GD组阳性检出率分别为72.7%和51.6%,GO组显著高于GD组(P<0.05)。结果TRAb在GO的诊断中具有重要意义;推测GD患者血清TRAb显著增高是合并或随病程延长可能合并GO的重要标志。
Objective To investigate the relationship between thyroglobulin antibody (TGAb), thyroid microsomal antibody (TMAb), thyroid receptor antibody (TRAb) and Graves’ ophthalmopathy (GO) and to investigate the role of each index in the pathogenesis of GO. Methods TGAb, TMAb and TRAb were measured by radioimmunoassay in 64 patients with Graves’ Disease (GD) and 121 patients with GO. The detection values of TRAb and TRAb were compared between the two groups. Results There was no significant difference in serum TGAb and TMAb activity between the two groups (P> 0.05). The activity of TRAb in GO group and GD group was (28 ± 6) U / L and (11 ± 10) U / L respectively (P <0.05). The positive rates of GO and GD were 72.7% and 51.6% respectively, which were significantly higher in GO group than those in GD group (P <0.05). Results TRAb was of great significance in the diagnosis of GO. It is speculated that the serum TRAb level in patients with GD is significantly higher than that in patients with GO or may be associated with the prolonged course of GO.