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目的评价小剂量系统性糖皮质激素+沙利度胺治疗口咽部重型阿弗他溃疡(MjAU)的效果。方法 92例顽固性口咽部MjAU患者分成两组,治疗组50例,采用小剂量系统性糖皮质激素联合口服沙利度胺治疗;对照组40例,采用单纯中剂量系统性糖皮质激素治疗。结果治疗组病程15~180 d,平均(47.80±38.79)d,通过治疗14~41 d,平均(22.12±7.39)d后溃疡愈合;对照组病程12~145 d,平均(44.62±36.03)d,通过治疗12~36 d,平均(19.77±8.92)d愈合。两组治疗效果比较,差异无统计学意义(P>0.05)。结论小剂量系统性糖皮质激素+沙利度胺联合治疗与单纯中剂量糖皮质激素治疗顽固性口咽部MjAU有相似的效果。
Objective To evaluate the efficacy of low-dose systemic glucocorticoid plus thalidomide in the treatment of orphaned heavy-duty aphthous ulcer (MjAU). Methods Ninety-two patients with intractable oropharyngeal MjAU were divided into two groups. The treatment group (50 cases) was treated with low-dose systemic glucocorticoid plus oral thalidomide. The control group (40 cases) was treated with systemic glucocorticoid . Results The course of the treatment group was 15 ~ 180 days (mean, 47.80 ± 38.79 days). The ulcer healed after an average of (22.12 ± 7.39) days after 14 ~ 41 days of treatment. The average duration of the control group was (14.62 ± 36.03) days , By treatment of 12 ~ 36 d, the average (19.77 ± 8.92) d healing. There was no significant difference between the two groups (P> 0.05). Conclusions The combination of low-dose systemic glucocorticoid + thalidomide with MjAU in simple or moderate oral glucocorticoid treatment has a similar effect.