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目的分析聚乙二醇干扰素联合利巴韦林(pegylated interferon plus ribavirin,peg IFN-α/RVB)治疗慢性丙型肝炎(chronic hepatitis C,CHC)疗效的影响因素,以便辅助判断治疗效果及合理变换治疗方案。方法收集来自江苏省句容市人民医院CHC临床治疗患者的基线资料,采用单因素及多因素Logistic回归进行分析。结果本研究纳入371例CHC患者,总持续性病毒学应答(sustained virological response,SVR)率为64.7%。多因素Logistic回归分析结果显示,基线病毒载量HCV RNA高(OR=0.95,95%CI:0.91~0.99,P=0.012)、甲胎蛋白(alpha fetoprotein,AFP)水平异常(OR=0.87,95%CI:0.78~0.97,P=0.014)及空腹血糖(blood glucose,GLU)水平异常(OR=0.86,95%CI:0.78~0.95,P=0.004)者更不易获得SVR。结论 peg IFN-α/RVB治疗CHC患者的SVR率较高,基线病毒载量、AFP及GLU均是影响持续病毒学应答的危险因素。
Objective To analyze the influencing factors of pegylated interferon plus ribavirin (peg IFN-α / RVB) in the treatment of chronic hepatitis C (CHC) in order to help judge the effect of treatment Transform the treatment plan. Methods The baseline data of CHC patients from Jurong City People’s Hospital of Jiangsu Province were collected and analyzed by single factor and multivariate logistic regression. Results The study included 371 CHC patients with a sustained sustained virological response (SVR) rate of 64.7%. Multivariate logistic regression analysis showed that the baseline HCV RNA levels were significantly higher (OR = 0.95, 95% CI: 0.91-0.99, P = 0.012) and alpha fetoprotein (AFP) % CI: 0.78-0.97, P = 0.014) and abnormal blood glucose (GLU) level (OR = 0.86,95% CI: 0.78-0.95, P = 0.004). Conclusion The SVR rate of patients with CHC treated with peg IFN-α / RVB is high, and the baseline viral load, AFP and GLU are both risk factors for the sustained virological response.