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将9只狗的小肠总长度的30％,50％及75％的上端分别切除,观察其对移行性综合肌电(MMC)发生规律和红霉素诱发MMCⅢ相的影响。结果发现,所有小肠部分切除的狗,残余小肠的慢波节律均较小肠完整时相应部位明显减慢;75％上端小肠切除的狗,MMC活动消失。小肠完整的狗,静脉注射红霉素均能使MMCⅢ相提前发生;30％上端小肠切除的狗,红霉素仅在一半的实验中可诱发MMCⅢ相,50％及75％上端切除后,红霉素不能诱发MMCⅢ相。但静脉注射吗啡后在所有动物模型上均能诱发MMCⅢ相。提示小肠MMC的周期活动需要空肠以上小肠的存在,红霉素仅在小肠上端能诱发MMCⅢ相。
The total length of the small intestine of 9 dogs were excised at 30%, 50% and 75% respectively. The effect on MMC and the erythromycin-induced MMC Ⅲ phase were observed. The results showed that the slow wave rhythm of all the small intestine partially resected dogs and residual small intestines was significantly slower than that of the corresponding small intestine. The activity of MMC disappeared in 75% of upper resected small intestine. Small bowel intact dogs, intravenous injection of erythromycin can make MMC Ⅲ phase occurred in advance; 30% of the upper end of the small intestine resection dogs, erythromycin MMCIII phase can be induced in only half of the experiment, 50% and 75% of the upper resection, red MMC can not induce MMC Ⅲ phase. However, MMC was induced in all animal models after intravenous injection of morphine. Prompted the cycle of small intestine MMC requires the presence of jejunum over the small intestine, erythromycin only in the upper intestine can induce MMC Ⅲ phase.