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已知许多化学物质可以刺激或致敏T淋巴细胞(TLC),进而启动B淋巴细胞(BLC)的反应而引起自身免疫性疾病。这些化学物质可以不产生特异性抗体,也不引起Ⅳ型迟发性变态反应,因而不能用血清学方法或接触性皮炎试验检测其免疫活性。最近欧洲医学研究委员会毒理学顾问小组
Many chemicals are known to stimulate or sensitize T lymphocytes (TLCs), which in turn initiate the response of B lymphocytes (BLCs) to cause autoimmune diseases. These chemicals can not produce specific antibodies, nor cause delayed type IV allergic reactions, and therefore can not be detected by serological methods or contact dermatitis test its immunocompetence. Recent European Medical Research Council Toxicological Advisory Panel