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目的:研究仲景温胃颗粒对氨水致大鼠慢性萎缩性胃炎模型的影响。方法:SPF级Wistar大鼠,连续90 d饮用0.025%的氨水,造成慢性胃炎模型。观察仲景温胃颗粒对胃液酸度、胃蛋白酶活性、胃泌素及炎性细胞数的影响。结果:仲景温胃颗粒可增加胃液的酸度、胃蛋白酶的活性以及血清中胃泌素的水平,降低炎症细胞的数量,恢复胃黏膜组织病理变化。结论:仲景温胃颗粒对慢性萎缩性胃炎大鼠胃黏膜组织具有良好的治疗作用。
Objective: To study the effect of Zhongjing Wenwei granule on chronic atrophic gastritis model induced by ammonia in rats. Methods: SPF grade Wistar rats were fed with 0.025% aqueous ammonia for 90 consecutive days, resulting in chronic gastritis model. To observe the effect of Zhongjing Wenwei granule on acidity, pepsin activity, gastrin and inflammatory cells in gastric juice. Results: Zhongjing Wenwei granules can increase gastric acidity, pepsin activity and serum gastrin levels, reduce the number of inflammatory cells and restore gastric mucosal histopathological changes. Conclusion: Zhongjing Wenwei granule has a good therapeutic effect on gastric mucosa in rats with chronic atrophic gastritis.