论文部分内容阅读
作者采用6种栓剂基质(半合成椰油酯、半合成脂肪酸酯,可可豆脂、聚乙二醇和意大利产基质)制成阿司匹林栓剂作家兔直肠给药,并与静脉注射和口服片剂比较,测定血药浓度,得出相对和绝对生物利用度,并计算药物动力学参数。结果5种基质的阿司匹林栓剂的生物利用度之间无显著差别,说明半合成椰油酯和半合成脂肪酸酯二种基质,与可可豆脂、水溶性基质聚乙二醇以及意大利产基质所制阿司匹林栓剂的生物利用度是相同的。阿司匹林栓剂直肠吸收和口服片剂之间的生物利用度也没有显著差别.
The authors made aspirin suppositories for rectal administration in 6 suppository bases (semi-synthetic coconut oil, semi-synthetic fatty acid esters, cocoa butter, polyethylene glycol and Italian-made matrices) and compared with intravenous and oral tablets , Determination of plasma concentration, draw relative and absolute bioavailability, and calculate pharmacokinetic parameters. Results There was no significant difference in the bioavailability of aspirin suppositories between the five substrates, indicating that the two substrates of semi-synthetic coconut oil and semi-synthetic fatty acid esters, together with cocoa butter, water-soluble polyethylene glycol matrix and the Italian substrate The bioavailability of aspirin suppositories is the same. There was also no significant difference in the bioavailability between aspirin suppositories and oral tablets.