应用膜片钳全细胞技术研究普罗帕酮对单个心室肌细胞膜离子通道的影响。结果表明：普罗帕酮灌流浓度为１×１０－６，６×１０－６Ｍ时，钠峰值电流分别下降３５．０％、５２．８％，Ｐ均＜０．０１；灌流浓度为１×１０－６，３×１０－６，６×１０－６Ｍ时，Ｌ型钙电流的峰值电流分别下降１８．５％、２８．８％、４５．３％，Ｐ均＜０．０５；对内向整流性钾流基本无影响。可见普罗帕酮不单纯是钠通道阻滞剂，对钙通道也有较强的阻滞作用 Patch clamp whole cell technique was used to study the effect of propafenone on the ion channels of single ventricular myocytes. The results showed that when the concentration of propafenone perfusion was 1 × 10-6,6 × 10-6M, the peak current of sodium decreased by 35.0% and 52.8%, respectively, P <0.01; the perfusion concentration was 1 × 10 -6,3 × 10-6,6 × 10-6M, the peak current of L-type calcium current decreased by 18.5%, 28.8% and 45.3%, respectively, P <0.05; for inward rectification Little effect on potassium flow. Can be seen that propafenone is not simply a sodium channel blocker, calcium channel also has a strong block effect