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[目的]探讨不同剂量率射线对全身照射 (TBI)效应的影响。[方法]回顾分析67例恶性淋巴瘤、白血病患者的临床资料 ,其中自1995年7月～1999年2月采用剂量率3.8cGy/min～6.0cGy/min(低剂量率组 )进行TBI37例。自1999年3月～2001年6月采用剂量率10cGy/min～11.32cGy/min29例 ,22.6cGy/min1例共30例 (高剂量率组 )进行TBI。TBI总量7Gy～8Gy。[结果]骨髓移植均一次性植活。骨髓移植并发症的发生率 ,两组比较其差异无统计学意义。高剂量率组的复发率低于低剂量率组 (P<0.05)。[结论]采用10cGy/min剂量率 ,肺受量控制在7Gy的单次TBI,是安全、有效的骨髓移植预处理方案。
[Objective] To investigate the effect of different dose rate ray on total body irradiation (TBI) effect. [Methods] The clinical data of 67 patients with malignant lymphoma and leukemia were retrospectively analyzed. From July 1995 to February 1999, 37 patients with TBI were used with dose rates ranging from 3.8 cGy/min to 6.0 cGy/min (low dose rate group). From March 1999 to June 2001, 29 patients with dose rates ranging from 10 cGy/min to 11.32 cGy/min and 22.6 cGy/min with 30 patients (high dose rate group) performed TBI. The total amount of TBI is 7 Gy to 8 Gy. [Results] Bone marrow transplantation was alive and one time. The incidence of complications of bone marrow transplantation was not statistically significant between the two groups. The recurrence rate of the high-dose rate group was lower than that of the low-dose rate group (P<0.05). [Conclusion] Using a 10cGy/min dose rate and a single TBI with a lung dose controlled at 7Gy is a safe and effective bone marrow transplantation preconditioning program.