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目的:探讨癫痫患儿苯巴比妥血药浓度与临床疗效、给药剂量、性别、年龄及体质量的相关性。方法:回顾性查阅我院127例次癫痫患儿苯巴比妥血药浓度监测记录,将浓度值、性别、年龄等资料录入数据库,利用SPSS13.0软件进行分析处理。结果:癫痫患儿苯巴比妥血药浓度值与性别不存在明显的相关性,但与给药剂量、年龄和体质量有关。结论:苯巴比妥在患儿体内的代谢与年龄和体质量相关,应根据血药浓度监测结果并结合患儿的自身情况来制订个体化给药方案。
Objective: To investigate the correlation between phenobarbital plasma concentration and clinical efficacy, dosage, sex, age and body weight in children with epilepsy. Methods: The monitoring records of phenobarbital blood concentration in 127 cases of epilepsy in our hospital were retrospectively reviewed. The data of concentration, sex and age were entered into the database and analyzed by SPSS13.0 software. Results: There was no significant correlation between blood concentration of phenobarbital and gender in children with epilepsy, but it was related to dose, age and body weight. Conclusion: The metabolism of phenobarbital in children is related to age and body mass. Individualized dosing regimens should be formulated based on the results of plasma concentration monitoring and the children’s own condition.