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GnRH脉冲注射诱导排卵已有十余年历史。但对给药途径、间隔时间及剂量的报道很不一致。本文目的是研究经静脉每90分钟注射GnRH 1次诱导排卵时,不同病因所致持续无排卵患者所需的有效剂量。研究对象为40例持续无排卵患者90个治疗周期。特发性低促性腺激素性性腺功能低减(IHH)9例,16周期;功能性下丘脑性闭经13例,27周期;正常雄激素性月经稀发6例,13周期;多囊卵巢综合征(PCOS)12例,34周期。全组24例要求生育。GnRH初始剂量为每脉冲5μg。每2～4天行B超及血E_2测定进行监测,治疗16～20大后仍无卵泡生长,则按每脉冲2.5μg递增剂量,直至排卵。黄体
GnRH pulse injection induced ovulation has more than ten years of history. However, the route of administration, interval time and dose reported very inconsistent. The purpose of this paper is to study the effective doses required for continuous anovulatory patients due to different etiologies when GnRH is injected once intravenously every 90 minutes. The object of study was 40 cycles of 90 cycles of anovulatory patients. Idiopathic hypogonadotropic hypogonadism (IHH) in 9 cases, 16 cycles; functional hypothalamic amenorrhea in 13 cases, 27 cycles; normal androgenic menstrual thin hair in 6 cases, 13 cycles; polycystic ovary syndrome Sign of (PCOS) in 12 cases, 34 cycles. The whole group of 24 require fertility. The initial dose of GnRH is 5 μg per pulse. Every 2 to 4 days line B and blood E_2 determination of monitoring, after treatment of 16 to 20 still no follicular growth, then 2.5μg per pulse escalating dose, until ovulation. Luteal