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内源性或获得性多药耐药性(MDR)是影响癌症治疗的问题之一,MDR 主要是由于耐药细胞质膜上 P-糖蛋白(P-gp)表达过度产生的。P-gp 通过降低细胞间抗癌药物的浓度积累产生耐药性。目前研究最广泛的MDR 逆转剂维拉帕米(verapamil,VRP)在
Endogenous or acquired multidrug resistance (MDR) is one of the problems that affect cancer treatment. MDR is mainly due to the overproduction of P-glycoprotein (P-gp) on the plasma membrane of drug resistant cells. P-gp produces resistance by reducing the accumulation of anticancer drugs in the cells. The most widely studied MDR reversal agent verapamil (VRP) is